Rutin

Introduction:

English name: Rutin

English alias: Vitamin P; Rutin

Appearance: Light yellow or light green crystalline powder

Relative molecular mass: 610.518

CAS RN: 153-18-4

EINECS number: 205-814-1

Molecular formula: C27H30O16

Melting point: 195 ℃

Density: 1.827 g/cm³

Solubility: Soluble in pyridine, formyl and alkali solution, slightly soluble in ethanol, acetone and ethyl acetate, almost insoluble in water, chloroform, ether, benzene, carbon disulfide and petroleum ether.

Content: ≥99% (HPLC)

Rutin, also known as rutin and vitamin P, has a molecular formula of C27H30O16. It is a natural flavonoid glycoside and belongs to the flavonol glycoside widely present in plants. The two glycosides are glucose and rhamnose. The appearance is light yellow or light green crystalline powder. It is soluble in pyridine, formyl and alkali solution, slightly soluble in ethanol, acetone and ethyl acetate, and almost insoluble in chloroform, ether, benzene, carbon disulfide and petroleum ether. It has anti-inflammatory, antioxidant, anti-allergic and antiviral effects.

Preparation method

1. Rutin exists in rue leaves, tobacco leaves, orange peels, tomatoes, etc., and is particularly rich in Sophora japonica rice and buckwheat flowers. The medicinal rutin in my country is extracted from Sophora japonica rice. After washing, Sophora japonica rice is boiled with hot water and lime milk (adjust pH to 7.5-8) for 20 minutes, borax is added, and it is kept warm at 95-100℃ for half an hour. Filter while hot, adjust the filtrate to pH=6-7 with hydrochloric acid, cool to below 30℃, stand and precipitate crystals, separate, and obtain crude rutin. After dissolution, recrystallization and drying, the finished product is obtained. The total yield is 8.3% based on Sophora japonica rice.

2. After the raw material (generally Sophora japonica buds) is crushed, it is extracted with hot ethanol, and then crystallized and refined with ether, hot methanol and hot water for many times. The residue obtained after the extract is concentrated is used to remove other soluble pigments and other impurities with a solvent, and then it is crystallized and refined with ethanol, ether, hot methanol and hot water for many times and activated carbon to obtain a high-purity substance.

Uses

1. Food coloring (similar to lemon yellow); antioxidant; nutritional supplement. Mainly used in cold drinks, beverages, cakes, meat processing products, aquatic processing products, etc.

2. Vitamin drugs. It has the effect of reducing the permeability and fragility of capillaries, maintaining and restoring the normal elasticity of capillaries. It is used to prevent and treat hypertensive cerebral hemorrhage, diabetic retinal hemorrhage and hemorrhagic purpura, etc., and is also used as a food antioxidant and pigment.

3. It has anti-inflammatory effect; vitamin P-like effect, which can maintain vascular resistance, reduce its permeability, reduce fragility, etc. It has a fat-removing effect on fatty liver, and the fat-removing effect is more obvious when used in combination with glutathione; it has antiviral effect and inhibits aldose reductase.