Introduction
Product Name: Cefoperazone Sodium
CAS NO: 62893-20-3
Purity: 99%min
Appearance:White to off white powder
Molecular formula:C25H28N9NaO8S2
Molecular weight :669.66
Melting Point :200-202°C
Solubility :Soluble in water. Slightly soluble in alcohol.
Storage :Keep in dark place,Inert atmosphere,2-8°C
Cefoperazone sodium salt is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM. Target: Antibacterial Cefoperazone is a sterile,
semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g of Cefoperazone,
levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level
is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.
| TEST ITEMS | STANDARD PRESCRIBE | RESULTS |
| Description | A white or almost white powder | Conforms |
| Identification | Positive | Conforms |
| Clarity and color of solution | ≤0.5" | less than 0.5" |
| ≤Y3" | less than Y2" | |
| Water | Not more than 3.5% | 1.6% |
| Particulate matter | Particules≥10μm:Max 3000 | 139 |
| Particules≥25μm: Max 300 | 3 | |
| Related substances | Not more than 3.0% | 1.6% |
| Bacterial endotoxins | Not more than 0.125EU per mg | Conforms |
| Sterility | Meets the requirements | Conforms |
| Assay(as cefoperazone) | Not more than 450μg of cefoperazone (C25H27N9O8S2) per mg on anhydrous basis | 454μg/mg |
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